MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16–amino acid peptide encoded within the mitochondrial genome — often referred to as a “metabolic regulator”. It plays a critical role in maintaining cellular energy balance by influencing how the body uses glucose and fatty acids for fuel. Research shows that MOTS-c levels naturally increase during exercise, suggesting it helps the body adapt to metabolic stress, enhance endurance, and support healthy aging.
COA / HPLC / MS
View the available third-party testing documentation for this product.
What's Included
Key Highlights
Metabolic Regulation
MOTS-c promotes efficient glucose and fat utilization, supporting balanced energy production at the cellular level.
Improved Exercise Performance
Enhances endurance and muscle strength by improving mitochondrial energy output and reducing fatigue.
Insulin Sensitivity Support
Helps regulate glucose levels and improve insulin response, potentially aiding in the prevention of metabolic disorders like diabetes.
Cellular Protection
Protects cells from oxidative and metabolic stress, supporting longevity and healthier aging.
Bone Health and Growth
Encourages osteoblast differentiation, supporting stronger bones and preventing age-related bone loss.
Fat Metabolism
Promotes fatty acid oxidation and helps maintain metabolic flexibility, supporting a leaner body composition.
What Is MOTS-c?
MOTS-c is a mitochondrial-derived peptide (MDP) that helps regulate energy metabolism and protect cells from stress. It signals within cells to promote metabolic balance, increase insulin sensitivity, and improve mitochondrial performance — all essential for sustained energy, fat metabolism, and muscle endurance. Because it directly impacts the mitochondria — the cell’s “powerhouses” — MOTS-c is being studied for its potential to combat metabolic diseases, obesity, and age-related decline.
Why Choose MOTS-c?
MOTS-c stands out as one of the few peptides coded by the mitochondrial genome, giving it a direct influence on how the body manages energy. Its ability to mimic the beneficial effects of exercise — improving endurance, metabolism, and insulin sensitivity — makes it highly valuable for research into metabolic health, athletic performance, and longevity.
Manufactured under strict ISO and cGMP-like conditions, MOTS-c undergoes HPLC purity testing and third-party verification to ensure consistency and reliability in every batch.
MOTS-c FAQs
What does MOTS-c do in the body?
MOTS-c helps regulate energy metabolism, enhances mitochondrial function, and protects against metabolic stress, making it essential for endurance and cellular health.
How is MOTS-c different from other peptides?
Unlike most peptides coded in the nuclear genome, MOTS-c is encoded in the mitochondrial DNA, allowing it to directly affect energy production and metabolic adaptation.
Can MOTS-c help with weight management?
Research suggests it promotes fat oxidation and improves insulin sensitivity, which may support a healthier metabolism and prevent obesity.
Does MOTS-c mimic exercise effects?
Yes — studies show MOTS-c levels rise during physical activity, helping improve energy efficiency and endurance similar to the effects of exercise.
Is MOTS-c used for anti-aging research?
Yes. Its ability to maintain mitochondrial health and protect against cellular stress makes it a strong candidate in longevity and anti-aging research.